Troxerutin

Trihydroxyethylrutoside · Trihydroxyethylrutin

Snapshot

Indications	Contraindications
Chronic venous insufficiency¹ Leg edema in venous disease¹ Hemorrhoidal bleeding² Acute hemorrhoidal symptoms^{3, 4} Post-hemorrhoidectomy symptoms⁵	Pregnancy or nursing⁶ Hepatitis history (coumarin combos)⁷

Troxerutin is a hydroxyethylated derivative of rutin⁸. It is used in a combination product with ginkgo and heptaminol that is described as a venotonic, strengthening vein walls and reducing capillary permeability⁹. Supplementation follows from that effect: leg swelling and heaviness in chronic venous insufficiency, and bleeding and discomfort in hemorrhoidal disease. Typical users are adults with venous symptoms who are often already wearing compression stockings.

Most trials test troxerutin inside combinations. A coumarin-troxerutin product limited recurrent leg swelling after compression stockings were stopped¹. A flavonoid mixture containing troxerutin controlled hemorrhoidal bleeding about as well as a diosmin-based comparator². Cochrane and systematic reviews in lymphoedema and retinal vein occlusion found insufficient or limited evidence of benefit^{10, 11}. A 2026 review of cell and animal studies described antiproliferative and pro-apoptotic activity in cancer models; no human trial has tested this⁸. Eight products listing troxerutin are sold, mostly as capsules in combination formulas; see Form comparison.

In a placebo-controlled trial of a coumarin-troxerutin combination, liver enzyme elevations were transient and tied to prior hepatitis or liver disease⁷. Per United States product labels, patients on prescription medications are told to consult their physician about interactions⁶.

Last updated October 17, 2026. Read how we make monographs.

In the full monograph

46 sources, 41 studies

When to useThe situations practitioners use it for, each with the reason and the study behind it.
SafetyWho should avoid it, who needs extra care, and the side effects reported in studies.
InteractionsThe medicines and supplements it interacts with, the effect of each, and what labeling says to watch.
Protocol notesThe doses used in studies, how and when they were taken, and how the forms on the market compare.
How it worksWhat it is and how it works in the body, in plain terms.
Published studiesThe studies behind each use, popular claims checked against them, and trials still under way.
Word of mouthWhat patients and practitioners report online, kept separate from the clinical evidence.
Clinical perspectiveA closing read of where the evidence is solid, where it is thin, and what has not been studied.

Snapshot

In the full monograph

Sources