Noni

Morinda citrifolia · Noni juice

Snapshot

Indications	Contraindications
Oxidative stress in smokers^{1, 2} Postoperative nausea³ Immune biomarkers⁴ Smoking-related lipid changes⁵	Kidney disease or potassium restriction⁶ Phenytoin therapy⁷ Warfarin therapy⁵ Pregnancy or nursing⁸

Noni (Morinda citrifolia) is an evergreen tree of the Pacific Islands and Southeast Asia whose fruit, taken as juice, extract, or powder, is promoted for immune and digestive health, energy, and aging skin⁶. It is thought to act through antioxidant and immune-modulating activity⁶. Its best-studied use in people is antioxidant support in heavy smokers^{1, 2}.

The fact sheet from the National Center for Complementary and Integrative Health (NCCIH) states that noni has not been shown to benefit any health condition in human studies⁶. Trials in heavy smokers found fewer oxidative damage markers, and a preoperative trial found less early postoperative nausea at the highest extract tested. A 2026 trial of fermented noni polysaccharides in adults with recurrent upper respiratory infections showed immune-marker shifts but no difference in infection incidence. In men on active surveillance for low-risk prostate cancer, a 2021 uncontrolled case series found noni capsules well tolerated with stable prostate-specific antigen; no controlled trial has tested it. Products listing noni number about 540 in the National Institutes of Health (NIH) label database, mainly liquid juices and capsules; see Form comparison.

LiverTox rates noni a probable rare cause of clinically apparent liver injury, idiosyncratic in pattern, with onset after 2 to 8 weeks and resolution on discontinuation⁹. Per NCCIH, people taking any medicine are told to talk with their health care provider before using noni⁶.

Last updated October 16, 2026. Read how we make monographs.

In the full monograph

39 sources, 29 studies

When to useThe situations practitioners use it for, each with the reason and the study behind it.
SafetyWho should avoid it, who needs extra care, and the side effects reported in studies.
InteractionsThe medicines and supplements it interacts with, the effect of each, and what labeling says to watch.
Protocol notesThe doses used in studies, how and when they were taken, and how the forms on the market compare.
How it worksWhat it is and how it works in the body, in plain terms.
Published studiesThe studies behind each use, popular claims checked against them, and trials still under way.
Word of mouthWhat patients and practitioners report online, kept separate from the clinical evidence.
Clinical perspectiveA closing read of where the evidence is solid, where it is thin, and what has not been studied.

Snapshot

In the full monograph

Sources