Nicotinamide Mononucleotide

NMN · beta-Nicotinamide mononucleotide

Snapshot

Indications	Contraindications
Blood NAD+ levels^{1, 2} Diastolic blood pressure^{3, 4} Biological age markers^{2, 5}	Pregnancy or breastfeeding⁶ Under 18 years⁷

Nicotinamide mononucleotide (NMN) is a vitamin B3-derived intermediate that feeds biosynthesis of nicotinamide adenine dinucleotide (NAD)⁸. Supplementation aims to restore NAD+, which is thought to decline with age, and is taken for healthy aging, physical performance, and cardiometabolic markers such as blood pressure and lipids. Oocyte quality is a further use, supported so far by animal work⁹. The typical patient is a middle-aged or older adult.

Human trials consistently show higher blood NAD levels and good tolerability, but functional and metabolic outcomes are mostly null or endpoint-specific^{5, 10}. In adults over 60, a meta-analysis found no effect on muscle mass or function¹¹. In a 2026 mouse study, NMN attenuated aortic dilation in an aneurysm model; no human trial has tested it. Products listing NMN number 282 in United States label data, mostly capsules and powders, and a microcrystalline polymorph is used in clinical trials; see Form comparison¹².

Health Canada labels ask for a practitioner's advice before use in diabetes⁶. Some Health Canada-licensed products also state that pregnant or breastfeeding patients should not use them⁶.

Last updated October 16, 2026. Read how we make monographs.

In the full monograph

50 sources, 36 studies

When to useThe situations practitioners use it for, each with the reason and the study behind it.
SafetyWho should avoid it, who needs extra care, and the side effects reported in studies.
Protocol notesThe doses used in studies, how and when they were taken, and how the forms on the market compare.
How it worksWhat it is and how it works in the body, in plain terms.
Published studiesThe studies behind each use, popular claims checked against them, and trials still under way.
Word of mouthWhat patients and practitioners report online, kept separate from the clinical evidence.
Clinical perspectiveA closing read of where the evidence is solid, where it is thin, and what has not been studied.

Snapshot

In the full monograph

Sources