Diosmin

Micronized purified flavonoid fraction · Daflon

Snapshot

Indications	Contraindications
Chronic venous disease symptoms¹ Lower-limb edema² Hemorrhoidal bleeding³ Venous ulcer healing (adjunct)⁴ Pelvic congestion syndrome⁵ Swelling after knee arthroplasty⁶ Post-thrombotic syndrome prevention⁷	Pregnancy or nursing⁸ Children under 18⁸

Diosmin is a flavonoid glycoside obtained from citrus rinds, usually by conversion of hesperidin, and is given alone or as micronized purified flavonoid fraction (MPFF), which is mostly diosmin with a small hesperidin share. It acts as a venoactive compound, supporting venous tone, endothelial barrier integrity, and lymphatic drainage while limiting leukocyte adhesion and inflammatory mediator release⁹. People take it for leg symptoms and edema in chronic venous disease, for hemorrhoidal bleeding and pain, for pelvic congestion symptoms, and for swelling after knee arthroplasty. Typical patients are middle-aged adults, predominantly women, with heavy, swollen, or aching legs⁴.

A meta-analysis of MPFF in chronic venous disease found reduced ankle and calf circumference and less feeling of swelling, though heterogeneity among studies was high². A randomized trial in total knee arthroplasty found less swelling and less pain during motion with diosmin, without more short-term complications⁶. Products come as non-micronized diosmin, MPFF, and diosmin-hesperidin combinations, and a review found no clinical advantage for micronization or added hesperidin on venous symptoms; see Form comparison¹⁰.

Last updated October 16, 2026. Read how we make monographs.

In the full monograph

72 sources, 59 studies

When to useThe situations practitioners use it for, each with the reason and the study behind it.
SafetyWho should avoid it, who needs extra care, and the side effects reported in studies.
InteractionsThe medicines and supplements it interacts with, the effect of each, and what labeling says to watch.
Protocol notesThe doses used in studies, how and when they were taken, and how the forms on the market compare.
How it worksWhat it is and how it works in the body, in plain terms.
Published studiesThe studies behind each use, popular claims checked against them, and trials still under way.
Word of mouthWhat patients and practitioners report online, kept separate from the clinical evidence.
Clinical perspectiveA closing read of where the evidence is solid, where it is thin, and what has not been studied.

Snapshot

In the full monograph

Sources