Dihydromyricetin

Ampelopsin

Snapshot

Indications	Contraindications
Hangover, Hovenia dulcis extract¹ Fatty liver disease^2–4 Low-density lipoprotein cholesterol³ Glycemic control⁵ Plasma adiponectin⁶	Pregnancy or nursing⁷ Under age 18⁷

Dihydromyricetin, also called ampelopsin, is a plant flavonoid from Ampelopsis grossedentata and Hovenia dulcis, sold in capsules in the United States as a supplement to prevent alcohol hangovers⁸. Its antioxidant and anti-inflammatory activity underlies use for alcohol-related liver stress¹. The same activity underlies use for fatty liver disease, lipids, and glycemic control, typically in adults with metabolic risk.

Human research is limited to about three small trials, in fatty liver disease and type 2 diabetes. A systematic review found robust preclinical benefit against alcohol-induced injury, but the clinical evidence was two small trials of Hovenia dulcis extract, not isolated dihydromyricetin¹. Products listing dihydromyricetin are mostly capsules and powders; poor bioavailability drives formulation efforts, covered in Form comparison.

The National Institutes of Health LiverTox review rates it an unlikely cause of clinically apparent liver injury⁹. Per product labels in the United States, most direct people taking medications to consult a health care professional first⁷.

Last updated October 16, 2026. Read how we make monographs.

In the full monograph

29 sources, 18 studies

When to useThe situations practitioners use it for, each with the reason and the study behind it.
SafetyWho should avoid it, who needs extra care, and the side effects reported in studies.
InteractionsThe medicines and supplements it interacts with, the effect of each, and what labeling says to watch.
Protocol notesThe doses used in studies, how and when they were taken, and how the forms on the market compare.
How it worksWhat it is and how it works in the body, in plain terms.
Published studiesThe studies behind each use, popular claims checked against them, and trials still under way.
Word of mouthWhat patients and practitioners report online, kept separate from the clinical evidence.
Clinical perspectiveA closing read of where the evidence is solid, where it is thin, and what has not been studied.

Snapshot

In the full monograph

Sources