Calcium D-Glucarate

D-glucaric acid · Calcium glucarate · Glucarate

Snapshot

Indications	Contraindications
Estrogen elimination¹ Estrogen metabolism support² Urinary detox markers, combo product³ Breast cancer supportive care¹ Lipid lowering²	Pregnancy or nursing⁴ Under age 18⁴

Calcium D-glucarate is the calcium salt of D-glucaric acid, which occurs naturally in oranges, apples, and cruciferous vegetables. The glucarate component is converted to an inhibitor of beta-glucuronidase, which supports elimination of estrogen and other glucuronidated compounds¹. Supplementation follows from that effect and is used for estrogen metabolism and general detoxification. Patients with breast cancer sometimes self-medicate with it after surgery or adjunctive treatment¹.

No clinical trial has tested these effects in humans; the evidence rests on rodent studies in which tumor number and growth fell after carcinogen exposure¹. In mouse skin models, a 2015 study found that a topical combination of butyric acid, nicotinamide, and calcium glucarate enhanced chemopreventive effects, and no human trial has tested it¹. The market lists 58,158 products listing calcium D-glucarate, sampled products being capsules and tablets; see Form comparison.

US product labels warn against use in pregnancy or nursing, and most others route pregnant, nursing, or medicated users to a physician before use⁴.

Last updated October 15, 2026. Read how we make monographs.

In the full monograph

25 sources, 9 studies

When to useThe situations practitioners use it for, each with the reason and the study behind it.
SafetyWho should avoid it, who needs extra care, and the side effects reported in studies.
Protocol notesThe doses used in studies, how and when they were taken, and how the forms on the market compare.
How it worksWhat it is and how it works in the body, in plain terms.
Published studiesThe studies behind each use, popular claims checked against them, and trials still under way.
Word of mouthWhat patients and practitioners report online, kept separate from the clinical evidence.
Clinical perspectiveA closing read of where the evidence is solid, where it is thin, and what has not been studied.

Snapshot

In the full monograph

Sources