Bilberry
Vaccinium myrtillus · European Blueberry · Whortleberry · Anthocyanins
Snapshot
| Indications | Contraindications |
|---|---|
Bilberry (Vaccinium myrtillus) is a European relative of the blueberry whose fruit and leaves have traditionally been used for vision, blood sugar, and cardiovascular conditions7. Its anthocyanins are thought to act through antioxidant and anti-inflammatory activity8. Supplementation is used for eye fatigue and visual function, for cognition and mood, and for cardiometabolic risk markers.
The National Center for Complementary and Integrative Health (NCCIH) reports that the most rigorous trials found no night vision benefit in healthy people7. A systematic review in myopia found anthocyanin-rich extracts improved mesopic contrast sensitivity and eye fatigue but did not consistently slow progression1. In a 2021 single-arm study of adults with controlled glaucoma, a pine bark and bilberry combination lowered intraocular pressure; no controlled trial has tested it. Products include capsules, liquid extracts, powders, and softgels; see Form comparison.
Bilberry has reported antiplatelet activity, so a bleeding interaction with aspirin and other nonsteroidal anti-inflammatory drugs is possible; the support is case reports, animal, and in vitro data9. Per NCCIH, people taking any medicine are told to talk with their health care provider before using bilberry7.
Last updated October 16, 2026. Read how we make monographs.
In the full monograph
44 sources, 39 studies
- When to useThe situations practitioners use it for, each with the reason and the study behind it.
- SafetyWho should avoid it, who needs extra care, and the side effects reported in studies.
- InteractionsThe medicines and supplements it interacts with, the effect of each, and what labeling says to watch.
- Protocol notesThe doses used in studies, how and when they were taken, and how the forms on the market compare.
- How it worksWhat it is and how it works in the body, in plain terms.
- Published studiesThe studies behind each use, popular claims checked against them, and trials still under way.
- Word of mouthWhat patients and practitioners report online, kept separate from the clinical evidence.
- Clinical perspectiveA closing read of where the evidence is solid, where it is thin, and what has not been studied.
Sources
- 1Nutritional Supplementation for Myopia Prevention and Control: A Systematic Review of Randomized Controlled Trials.pubmed.ncbi.nlm.nih.govMartinez-Perez, Oliveira · Nutrients · 2025 · Pubmed
- 2The effect of anthocyanins and anthocyanin-rich foods on cognitive function: a meta-analysis of randomized controlled trials.pubmed.ncbi.nlm.nih.govMicek, Godos, Giampieri et al. · GeroScience · 2026 · Pubmed
- 3In vitro mechanistic studies and potential health benefits of a standardized bilberry extract in low mood and cognitive enhancement.pubmed.ncbi.nlm.nih.govKara, Hasbal-Celikok, Wilson et al. · Frontiers in nutrition · 2025 · Pubmed
- 4Effects of a Flavonoid-Rich Blackcurrant Beverage on Markers of the Gut-Brain Axis in Healthy Females: Secondary Findings From a 4-Week Randomized Crossover Control Trial.pubmed.ncbi.nlm.nih.govGillies, Wilson, Miller et al. · Current developments in nutrition · 2024 · Pubmed
- 5Systematic Review of Anthocyanins and Markers of Cardiovascular Disease.pubmed.ncbi.nlm.nih.govWallace, Slavin, Frankenfeld · Nutrients · 2016 · Pubmed
- 6US product labelsdsld.od.nih.govWarnings printed on US dietary supplement labels with this ingredient, from the NIH Office of Dietary Supplements' Dietary Supplement Label Database (DSLD). Manufacturers' precautions, not evidence of harm
- 7NCCIHnccih.nih.govNational Center for Complementary and Integrative Health
- 8A Review of Major Compounds in Bilberry (Vaccinium myrtillus L.) Fruits and Leaves: Isolation, Purification, and Their Antiaging Effects.pubmed.ncbi.nlm.nih.govPatra, Shin, Das · Nutrients · 2026 · Pubmed
- 9Herbal medication: potential for adverse interactions with analgesic drugs.pubmed.ncbi.nlm.nih.govAbebe · Journal of clinical pharmacy and therapeutics · 2002 · Pubmed